Firstly, physicians see adhesions, adhesion pain, adhesion causes and adhesion surgery completely differently to lay people.

There is a huge gap between patient education and field work WITH patients. To this end EndoGyn created a site to exchange views, for discussion, to educate, to teach and to learn.

Adhesions are very difficult to treat and adhesion treatment is a challenge for the medical and scientific community. Nothing is 100 % certain, nothing is guaranteed, there is no standard treatment, no available medication guarantees success – some seemingly successful medications have even been withdrawn from the market suddenly. So we need to work together and not be distracted by the unproven remarks of a minority who unfortunately did not get the results they wished for from surgery or those who didn’t have any surgery with me at all!

Those who complain are those who normally did not get the results that they wished for. Generally, there is little feedback from the successful cases since they have resumed their normal lives and don’t have a need for patient support organisations or to post comments on message boards. This should be taken into consideration when making any comments about treatment.

I will try to explain what adhesions and adhesion surgery are. I will do this regularly, and in the context of Helen’s ARD course where I can refer to her explanations. This is, by the way, a good example of an excellent patient-doctor relationship.

1) The surgeons describe adhesions using a SCORE system: firstly by the number of adhesions (e.g. covering an area of 15 cm) and, secondly, by their severity (how they are attached to the organs, how dense, filmy, etc), and how they can be removed (sharp dissection, bloodless cutting, etc). There is much more to a surgeon’s view on adhesions than meets the eye. We see an improvement of the adhesion score as a success, whereas the patient often sees an improvement of symptoms or a complete disappearance of symptoms as a success!

2) After surgery some adhesions may return. Again, we measure this by scoring, so we might have an improvement of an adhesion situation while the patient says s(h)e has pain and therefore concludes the adhesions are back!

In some cases there may be a huge improvement of adhesions (by 90%), but some small adhesions might have formed somewhere and cause extreme pain. Small adhesions can even cause bowel obstructions (briden ileus)! 
Overall, even if a surgeon reduces adhesions by 90% (as in this individual case), the patient has pain that returns and therefore considers the procedure to be a total failure (0% healed).

Do you see the difference?

Consider the following option: In the event a patient develops pain again, it would take only 30 minutes of surgery to remove this small adhesion that causes the pain. This would represent a 100% healing (100% success) using a minor procedure. That is how fine the line is between surgical success or failure! 
In the follow-up many could improve their situations and we can all learn and contribute to finding better solutions to ARD problems! 

3) All cases of adhesion are unique and every patient reacts differently to surgery, pain, adhesion barriers, etc, SO no conclusions can be made from one individual case. The only factors which can be taken into account are the results of the whole group under investigation. If individual outcomes would be used to gauge the success of a medical product or treatment, medical science would stagnate since there are always a few negative results, and those are the patients who tend to complain.

Our results reflect the global group and not individuals. For those who had „no success“ there is an option which I mentioned above which can lead to improved individual results.

We also have to exclude some individuals from the group. In order to assess the success rate of an adhesion treatment, we have to divide all patients who had the same treatment, the same adhesion SCORE (amount of adhesions and their severity) into small sub-groups to estimate the results and compare them to each other. We would otherwise be comparing apples to pears.

For example, patients with adhesions covering an area of about 20 cm have to be viewed together and can’t be compared to patients who have an area of 5 cm or where the entire abdomen is full of adhesions (around 50 cm of adhesions). For a correct comparison, even groups of healthy and ill patients in every sub-group would have to be assessed, and so on.

Simply put, we compare the adhesion score (number of adhesions) and the severity score of adhesions at initial surgery, with the scores in the second examination and we come to a long term follow-up. In our first protocol we include only patients with a follow-up of at least 3 months. We exclude all patients with the following criteria:

No second examination laparoscopy 
Further surgery (e.g. gall bladder, appendix) 
Patients with complications during initial surgery or second examination 
An infection after the initial surgery (e.g. peritonitis) 
2nd surgery not in our facility and without proper documentation of the previous surgery sites 
Refusal of the follow-up or second-look operation.

Just to clarify a point, gall bladder surgery can also cause adhesions in the lower pelvis as there is blood that coagulates, seeping down to the lower part of the body when the patient is standing. This is how you can develop adhesions in the pelvis area after the upper organs have been operated on.

All patients with pain need to confirm that their pain is associated with a reformation of adhesions and not to any other issues like gastritis, pancreatitis, stress, individual issues and other factors. This is best done by a 3rd laparoscopy offered in our concept of adhesion treatments. These adhesions have to be well documented in images, as they might have consequences for the surgery procedure or the adhesion barrier. We offer this to our patients at no charge for the surgery itself if it is pperfromed in between of 12 weeks post initial surgery.

4) The whole peritoneum is an ORGAN that helps defend the abdominal cavity and therefore there is a permanent exchange of fluids and cells. It permanently builds new cells to prevent infections. In so doing it repairs itself, the integrity of the organ “peritoneum”.

A foreign body, like for instance your menstrual blood, causes irritation and local inflammation. Blood in general causes irritation. This is, for example, why endometriosis nearly always produces some adhesion, generally in the pelvic area and sometimes in the entire abdominal cavity. This, and surgery conducted on genital organs, is the reason why adhesions are more prevalent in women.

Infections, even slight ones, can cause inflammation, thus regenerating the peritoneum resulting in adhesions (scar tissue). This is a normal healing process. A good example is our skin. When you graze your skin after a fall, you will see how the skin heals. First it bleeds, then it forms a scab to prevent contamination with bacteria, then new skin forms under the scab and finally the scab falls off. Compared to a simple cut from a knife, this is a long healing process. Wounds covering a larger area are much more susceptible to infection and take longer to heal. 
The wounded tissue after adhesiolysis is comparable with the skin healing process. And the areas are sometimes very large. The main aim of adhesion surgery is to prevent infection. Proper equipment and antibiotics might help in some cases, but usually there is always a “reaction” to surgery. In some patients this might be slight, in others severe. In some cases this process can result in adhesion formation, in others not. If the regeneration process takes 8 weeks, the patient might develop adhesions in this period. In the case of an infection, it might even take up to 16 weeks.

Surgeons cannot guarantee that adhesiolysis will succeed, but we are doing our BEST!

To estimate risk, a second laparoscopy is a good tool to determine the chance of adhesion formation. Experiments show that adhesions form in the first 7 days after surgery, so if we don’t have adhesions 7 days after the initial adhesiolysis, and the patient doesn’t get any infection or undergoes any further surgery, we can conclude that there will be no adhesions. The concept of the 3rd examination of patients who have developed pain after the second examination (in a period of 12 weeks), allows us to confirm or exclude adhesion formation and to deal with it. This will occur within the mentioned 12 week period and after the second examination. Also, within this time frame the adhesion formation will be very minor and can be easily dealt with.

The results are as follows: 
All adhesion scores that were described in the literature mostly concerned genital organs and are therefore inappropriate for comparing scores of bowel adhesions. As most of our patients suffer from bowel adhesions and severe adhesion status, we developed our own score system. This will be published at a later date. 
Our adhesion treatment with gasless laparoscopic adhesiolysis and SprayGel there was applied to 9 German patients and 36 from other countries. Before the availability of SprayGel we performed adhesiolysis with gasless laparoscopy but without any adhesion barrier. Of the 45 patients only 27 could be included in the tests (see exclusion criteria above). 
18 patients had the following exclusion criteria: 
3 because of other surgery (gall bladder, appendicitis) 
5 with complications during initial surgery or second procedures or a frozen abdomen 
3 because there is no follow-up. 
7 with a follow-up shorter than 3 months 
Of 34 patients (27 + 7 with short follow-up) = 31 patients, 91 % were adhesion free at the 2nd laparoscopy at 7 days postoperative.

Three patients had small (less than 3 cm) adhesion attachments to the incision sites at the second examination 7 days post-operatively. These were removed very easy by simply touching them with an instrument. We assume that no adhesions will recur as none of these 3 patients have developed pain in the follow-up. 
Of the 27 patients, 4 developed pain after surgery, which means that 85 % of patients were free of pain 3 -13 months later.

Of the 4 patients with pain, 2 had a 3rd laparoscopy with no adhesions detected. This means that only two patients didn’t have a 3rd examination and might have adhesions (one of the patients is going to have her 3rd laparoscopy at the end of September).

Even if I assumed that these 2 remaining cases had adhesions, the adhesiolysis success rate procedure WOULD translate to 25 of 27 patients being adhesion and pain free, the equivalent of 92,6 %. 
If we extrapolate this even further to include another 3 with no follow-up (exclusion criteria) who complain about pain but decided to have no follow-up, and we count them as having adhesions, it would represent only 5 of 30 patients with 83 % adhesion and pain free!

I think the results are excellent. In my opinion there is a huge difference between gasless laparoscopy compared to laparoscopic adhesiolysis with carbon dioxide!

The literature on gynaecological adhesions (NOT bowel adhesions) reports 71 % adhesion free statuses at the second stage with no long-term follow-up. Others are reporting a rate of 63 % of patients with no pain. 
There is no other published research on (gasless)-laparoscopic adhesiolysis with an application of an adhesion barrier and a second laparoscopy with regard to severe bowel adhesions.

One should bear in mind that even very difficult cases which require more than one procedure to achieve an improvement in adhesion formation end up being better than before surgery. One could CREDIT our treatment as an enormous improvement, considering that no other surgeon would even think of operating on this patient.

——————– 
Dr. med. Daniel Kruschinski

Die meisten unserer Verwachsungslösungen (Adhäsiolyse) betreffen Darmverwachsungen.

Hier ist ein Fall mit gynäkologischen Adhäsionen, die einen Einfluss auf die Fertilität haben können oder Schmerzen verursachen.

Die linke Beckenwand is komplett mit Darm zugewachsen. Man kann lediglich die Spitze des linken Eierstocks (weiss) erkennen:

Nach durchgeführter lift-laparoskopischer Verwachsungslösung kann die weibliche Anatomie sehr gut erkannt werden:

linker Eierstock und linker Eileiter mit Fimbrienende.

Der Darm liegt an seiner korrekten anatomischen Position.

Applikation von Spraygel als Verwachsungsbarriere …

und in der Second-look Bauchspiegelung: keine Neubildung oder Reformation von Verwachsungen.

Wenn ein sog. künstliches MESH eingesetzt wird, z.B. für den Verschluss von Bruchpforten oder wie in diesem Fall für die

Stabilisierung eines TRAM-Flap (Brust Rekonstruktion mit dem Transversus abdominis Rektus Bauchmuskel), können sich

Verwachsungen zu diesem MESH bilden.

Diese Patientin aus Texas / USA wurde von Ihrem Chirurgen schon 4 mal operiert und die Verwachsungen kamen immer wieder.

Der Chirurg und seine OP-Schwester haben übrigens die Patientin zur Chirurgie nach Deutschland begleitet, um sich die

Verwachsungslösung bei uns anzuschauen.

Hier sind die Bilder:

Man erkennt das MESH Material, unter welchem sich die Verwachsungen gebildet haben.

Nach Lösen der Verwachsungen wurde SprayGel appliziert

in der Second look Laparoskopie sind keine Verwachsungen mehr zu sehen.

Und bei der gleichen Patientin, die eine Gebärmutterentfernung mit Bauschschnitt vor Jahren hatte, haben sich auch

Verwachsungen im unteren Bauch gebildet.

Hier sind Verwachsungen zur linken Beckenwand, die am Darm zweifach extrem ziehen.

 und nach Lösen dieser Verwachsungen 

wurde SprayGel appliziert 

und in der Second-look Laparoskopie haben sich in diesem Bereich keine Verwachsungen mehr gebildet.